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Journal Issue - Volume 159 Issue 1 (January 2010)

2010 Re-launch of BJP
JC McGrath
Published online on Jan 19, 2010
DOI: 10.1111/j.1476-5381.2009.00635.x (p 1-4)

Reducing QT liability and proarrhythmic risk in drug discovery and development
Jean-Pierre Valentin
Published online on Jan 19, 2010
DOI: 10.1111/j.1476-5381.2009.00547.x (p 5-11)

An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk
CE Pollard, N Abi Gerges, MH Bridgland-Taylor, A Easter, TG Hammond, J-P Valentin
Published online on Jan 19, 2010
DOI: 10.1111/j.1476-5381.2009.00207.x (p 12-21)

Dealing with hERG liabilities early: diverse approaches to an important goal in drug development
BD Guth, G Rast
Published online on Jan 19, 2010
DOI: 10.1111/j.1476-5381.2009.00265.x (p 22-24)

Value of non-clinical cardiac repolarization assays in supporting the discovery and development of safer medicines
Jean-Pierre Valentin, Chris Pollard, Pierre Lainée, Tim Hammond
Published online on Jan 19, 2010
DOI: 10.1111/j.1476-5381.2009.00530.x (p 25-33)

Update on the evaluation of a new drug for effects on cardiac repolarization in humans: issues in early drug development
Vaibhav Salvi, Dilip R Karnad, Gopi Krishna Panicker, Snehal Kothari
Published online on Sep 23, 2009
DOI: 10.1111/j.1476-5381.2009.00427.x (p 34-48)

The thorough QT/QTc study 4 years after the implementation of the ICH E14 guidance
B Darpo
Published online on Nov 18, 2009
DOI: 10.1111/j.1476-5381.2009.00487.x (p 49-57)

Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives
Rashmi R Shah
Published online on Jun 25, 2009
DOI: 10.1111/j.1476-5381.2009.00191.x (p 58-69)

Facts, fancies and follies of drug-induced QT/QTc interval shortening
Marek Malik
Published online on Jan 19, 2010
DOI: 10.1111/j.1476-5381.2009.00554.x (p 70-76)

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential
Najah Abi-Gerges, Jean-Pierre Valentin, Chris E Pollard
Published online on Aug 06, 2009
DOI: 10.1111/j.1476-5381.2009.00338.x (p 77-92)

Dexrazoxane protects the heart from acute doxorubicin-induced QT prolongation: a key role for I_Ks
J Ducroq, H Moha ou Maati, S Guilbot, S Dilly, E Laemmel, C Pons-Himbert, JF Faivre, P Bois, O Stücker, M Le Grand
Published online on Aug 24, 2009
DOI: 10.1111/j.1476-5381.2009.00371.x (p 93-101)

Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG-encoded potassium channel
R Männikkö, G Overend, C Perrey, CL Gavaghan, J-P Valentin, J Morten, M Armstrong, CE Pollard
Published online on Aug 10, 2009
DOI: 10.1111/j.1476-5381.2009.00334.x (p 102-114)

Integrated risk assessment and predictive value to humans of non-clinical repolarization assays
Robert M Wallis
Published online on Sep 28, 2009
DOI: 10.1111/j.1476-5381.2009.00395.x (p 115-121)

Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT_1A receptors
TV Zanelati, C Biojone, FA Moreira, FS Guimarães, SRL Joca
Published online on Dec 04, 2009
DOI: 10.1111/j.1476-5381.2009.00521.x (p 122-128)

Evidence that the plant cannabinoid cannabigerol is a highly potent α₂-adrenoceptor agonist and moderately potent 5HT_1A receptor antagonist
MG Cascio, LA Gauson, LA Stevenson, RA Ross, RG Pertwee
Published online on Dec 04, 2009
DOI: 10.1111/j.1476-5381.2009.00515.x (p 129-141)

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