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Journal Issue - Volume 159 Issue 5 (March 2010)

EDITORIAL
RJ Summers
Published online on Mar 10, 2010
DOI: 10.1111/j.1476-5381.2010.00695.x (p 983-985)

The impact of GPCR structures on pharmacology and structure‐based drug design
Miles Congreve, Fiona Marshall
Published online on Nov 13, 2009
DOI: 10.1111/j.1476-5381.2009.00476.x (p 986-996)

Rational design of dualsteric GPCR ligands: quests and promise
Klaus Mohr, Christian Tränkle, Evi Kostenis, Elisabetta Barocelli, Marco De Amici, Ulrike Holzgrabe
Published online on Feb 05, 2010
DOI: 10.1111/j.1476-5381.2009.00601.x (p 997-1008)

Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor
Erin E Cawston, Laurence J Miller
Published online on Nov 18, 2009
DOI: 10.1111/j.1476-5381.2009.00489.x (p 1009-1021)

Ligand‐directed signalling at β‐adrenoceptors
Bronwyn A. Evans, Masaaki Sato, Mohsin Sarwar, Dana S. Hutchinson, Roger J. Summers
Published online on Feb 02, 2010
DOI: 10.1111/j.1476-5381.2009.00602.x (p 1022-1038)

Mechanisms of multimodal sensing by extracellular Ca ²⁺ ‐sensing receptors: a domain‐based survey of requirements for binding and signalling
Mahvash A Khan, Arthur D Conigrave
Published online on Feb 05, 2010
DOI: 10.1111/j.1476-5381.2009.00603.x (p 1039-1050)

β‐arrestins – scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?
Gunnar Schulte, Alexandra Schambony, Vítězslav Bryja
Published online on Nov 03, 2009
DOI: 10.1111/j.1476-5381.2009.00466.x (p 1051-1058)

Structure–function relationships of the N‐terminus of receptor activity‐modifying proteins
Tao Qi, Debbie L Hay
Published online on Dec 10, 2009
DOI: 10.1111/j.1476-5381.2009.00541.x (p 1059-1068)

Phe369(7.38) at human 5‐HT ₇ receptors confers interspecies selectivity to antagonists and partial agonists
Thibault Varin, Hugo Gutiérrez‐de‐Terán, Marián Castro, José Brea, Frederic Fabis, François Dauphin, Johan Åqvist, Alban Lepailleur, Pilar Perez, Javier Burgueño, José Miguel Vela, Maria Isabel Loza, Jordi Rodrigo
Published online on Nov 18, 2009
DOI: 10.1111/j.1476-5381.2009.00481.x (p 1069-1081)

Genistein reduces glycosaminoglycan levels in a mouse model of mucopolysaccharidosis type II
A Friso, R Tomanin, M Salvalaio, M Scarpa
Published online on Feb 05, 2010
DOI: 10.1111/j.1476-5381.2009.00565.x (p 1082-1091)

Distinct expression and ligand‐binding profiles of two constitutively active GPR17 splice variants
T Benned‐Jensen, MM Rosenkilde
Published online on Feb 08, 2010
DOI: 10.1111/j.1476-5381.2009.00633.x (p 1092-1105)

A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain
RD Andó, B Méhész, K Gyires, P Illes, B Sperlágh
Published online on Feb 05, 2010
DOI: 10.1111/j.1476-5381.2009.00596.x (p 1106-1117)

The COX‐2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain
Maria Beatriz Goncalves, Emma‐Jane Williams, Ping Yip, Rafael J Yáñez‐Muñoz, Gareth Williams, Patrick Doherty
Published online on Feb 05, 2010
DOI: 10.1111/j.1476-5381.2009.00618.x (p 1118-1125)

Poly(lactic acid‐glycolic acid) nanoparticles markedly improve immunological protection provided by peptide P10 against murine paracoccidioidomycosis
André C Amaral, Alexandre F Marques, Julián E Muñoz, Anamélia L Bocca, Andreza R Simioni, Antonio C Tedesco, Paulo C Morais, Luiz R Travassos, Carlos P Taborda, Maria Sueli S Felipe
Published online on Feb 05, 2010
DOI: 10.1111/j.1476-5381.2009.00617.x (p 1126-1132)

Vasodilator therapy with hydralazine induces angiotensin AT ₂ receptor‐mediated cardiomyocyte growth in mice lacking guanylyl cyclase‐A
Y Li, Y Saito, K Kuwahara, X Rong, I Kishimoto, M Harada, M Horiuchi, M Murray, K Nakao
Published online on Feb 05, 2010
DOI: 10.1111/j.1476-5381.2009.00619.x (p 1133-1142)

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